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    • Targeting cell surface proteoglycans with high affinity multimeric ligands and their cytotoxic conjugates – towards precision medicine for pancreatic cancer
    • Structure-function relationship in fibroblast growth factors signaling
    • Extracellular galectins as controllers of fibroblast growth factor receptor signaling
    • Dual warhead conjugates against FGFR-dependent cancers
    • Uncovering the funtions of FGF homologous factors – FHFs
    • Finished Projects
      • FGF1 analogue as a novel therapy for the treatment of diabetes mellitus
      • Highly stable mutants of human Fibroblast Growth Factor-1 (FGF1)
      • Spatial organization of FGF receptor 1 by multimeric ligand assemblies
      • Cytotoxic FGFR-targeted peptibodies
      • In silico studies of Fibroblast Growth Factor
      • Antiapoptotic activity of human FGF1 i FGF2
      • Highly cytotoxic FGF2-conjugates in targeted therapy for FGFR-expressing cancers
      • Binding partners for FGF1 in nucleocytoplasmic translocation
      • Functional nanoparticles for medical applications
      • Aptamers
      • Repetitive scaffolds
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    • Publications 2011-Present
    • Publications 2001-2010
    • Publications 1983-2000
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Current interests of the group

Nanotechnology      Bioconjugates     Therapeutic proteins

Protein Engineering       Phage Display     Aptamers

Signal transduction FGF/FGFR

FHFs Galectins

High content screening

Multivalency Protein transport

Collaborations:

Prof. Antoni Więdłocha, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway

Prof. Dario Neri, Institute of Pharmaceutical Sciences, ETH, Zurich, Switzerland

Prof. Mariusz Jaskólski, Institute of Bioorganic Chemistry, PAS, Poznań, Poland

Prof. Arne Smalås, Department of Chemistry, University of Tromsø, Norway

Prof. Marta Miączyńska, Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, Warsaw

Prof. Yves St Pierre, INRS, Canada

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