2024

Gadaj A, Chorążewska A, Ciura K, Karelus R, Żukowska D, Biaduń M, Kalka M, Zakrzewska M, Porębska N, Opaliński Ł, The intracellular interplay between galectin-1 and FGF12 in the assembly of ribosome biogenesis complex. Cell Communication and Signaling, 2024, doi: 10.1186/s12964-024-01558-1.

Krzyscik MA, Porębska N, Opaliński Ł, Otlewski J. Targeting HER2 and FGFR-positive cancer cells with a bispecific cytotoxic conjugate combining anti-HER2 Affibody and FGF2. Int J Biology Macromol. Jan;254(Pt 1):127657. doi: 10.1016/j.ijbiomac.2023.127657.

2023

Porębska N, Ciura K, Chorążewska A, Zakrzewska M, Otlewski J, Opaliński Ł. Multivalent protein-drug conjugates – An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells. Biotechnol Adv. 2023 Oct:67:108213. doi: 10.1016/j.biotechadv.2023.108213.

Zukowska D, Gedaj A, Porebska N, Pozniak M, Krzyscik M, Czyrek A, Krowarsch D, Zakrzewska M, Otlewski J, Opalinski L. Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling. Cell Mol Life Sci. 2023 Apr 3;80(4):113. doi: 10.1007/s00018-023-04768-x.

Gregorczyk P, Porębska N, Żukowska D, Chorążewska A, Gędaj A, Malinowska A, Otlewski J, Zakrzewska M, Opaliński Ł. N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope. Cell Commun Signal. 2023 Jul 21;21(1):177. doi: 10.1186/s12964-023-01203-3.

Gedaj A, Zukowska D, Porebska N, Pozniak M, Krzyscik M, Czyrek A, Krowarsch D, Zakrzewska M, Otlewski J, Opalinski L. Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling. Cell Comm Signal. 2023 May 25;21(1):122. doi: 10.1186/s12964-023-01144-x.

Biadun M, Sochacka M, Karelus R, Baran K, Czyrek A, Otlewski J, Krowarsch D, Opalinski L, Zakrzewska M. FGF homologous factors are secreted from cells to induce FGFR-mediated anti-apoptotic response. FASEBJ. 2023 Jul;37(7):e23043. doi: 10.1096/fj.202300324R.

Lampart A, Krowarsch D, Biadun M, Sorensen V, Szymczyk J, Sluzalska K, Wiedlocha A, Otlewski J, Zakrzewska M. Intracellular FGF1 protects cells from apoptosis through direct interaction with p53. Cell Mol Life Sci, 2023 Oct 2;80(10):311. doi: 10.1007/s00018-023-04964-9.

Nawrocka D, Krzyscik MA, Sluzalska KD, Otlewski J. Dual-Warhead Conjugate Based on Fibroblast Growth Factor 2 Dimer Loaded with α-Amanitin and Monomethyl Auristatin E Exhibits Superior Cytotoxicity towards Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1. Int J Mol Sci. 2023 Jun 14;24(12):10143. doi: 10.3390/ijms241210143.

Szymczyk J, Czyrek A, Otlewski J, Zakrzewska M. FGF1 Protects MCF-7 Cells against Taltobulin through Both the MEKs/ERKs and PI3K/AKT Signaling Pathway. Biomedicines. 2023 Jun 29;11(7):1856. doi: 10.3390/biomedicines11071856.

2022

Sochacka M, Karelus R, Opalinski L, Krowarsch D, Biadun M, Otlewski J, Zakrzewska M. FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex. Cell Commun Signal. 2022 Nov 21;20(1):182. doi: 10.1186/s12964-022-01000-4.

Szymczyk J, Sochacka M, Chudy P, Opalinski L, Otlewski J, Zakrzewska M. FGF1 protects FGFR1-overexpressing cancer cells against drugs targeting tubulin polymerization by activating AKT via two independent mechanisms. Front Oncol. 2022 Oct 6:12:1011762. doi: 10.3389/fonc.2022.1011762. eCollection 2022.

Krzyscik MA, Opaliński Ł, Szymczyk J, Otlewski J. Cyclic and dimeric fibroblast growth factor 2 variants with high biomedical potential. Int J Biol Macromol. 2022 Oct 1:218:243-258. doi: 10.1016/j.ijbiomac.2022.07.105.

Poźniak M, Żukowska D, Gędaj A, Krzyścik MA, Porębska N, Zakrzewska M, Otlewski J, Opaliński Ł. The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases. Int J Mol Sci, 2022 Jul 31;23(15):8514. doi: 10.3390/ijms23158514.

Jendryczko K, Rzeszotko J, Krzyscik MA, Kocyła A, Szymczyk J, Otlewski J, Szlachcic A. Drug Conjugation via Maleimide-Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies. Mol Pharm. 2022 May 2;19(5):1422-1433. doi: 10.1021/acs.molpharmaceut.1c00946.

Lampart A, Sluzalska KD, Czyrek A, Szerszen A, Otlewski J, Wiedlocha A, Zakrzewska M. Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells. Cells. 2022 Feb 2;11(3):522. doi: 10.3390/cells11030522.

2021

Porębska N, Knapik A, Poźniak M, Krzyścik MA, Zakrzewska M, Otlewski J, Opaliński Ł. Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers. Biomacromolecules. 2021 Dec 13;22(12):5349-5362. doi: 10.1021/acs.biomac.1c01280.

Szymczyk J, Sluzalska KD, Materla I, Opalinski L, Otlewski J, Zakrzewska M. FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance. Cancers. 2021 Nov 18;13(22):5796. doi: 10.3390/cancers13225796.

Jendryczko K, Rzeszotko J, Krzyscik MA, Szymczyk J, Otlewski J, Szlachcic A. Peptibody Based on FGFR1-Binding Peptides From the FGF4 Sequence as a Cancer-Targeting Agent. Front Pharmacol. 2021 Nov 12:12:748936. doi: 10.3389/fphar.2021.748936. eCollection 2021.

Poźniak M, Porębska N, Jastrzębski K, Krzyścik MA, Kucińska M, Zarzycka W, Barbach A, Zakrzewska M, Otlewski J, Miączyńska M, Opaliński Ł. Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors. J Biomet Sci. 2021 Oct 11;28(1):69. doi: 10.1186/s12929-021-00767-x.

Krzyscik MA, Zakrzewska M, Sørensen V, Øy GF, Brunheim S, Haugsten EM, Mælandsmo GM, Wiedlocha A, Otlewski J. Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model. Biomacromolecules. 2021 Oct 11;22(10):4169-4180. doi: 10.1021/acs.biomac.1c00662.

Sluzalska KD, Slawski J, Sochacka M, Lampart A, Otlewski J, Zakrzewska M. Intracellular partners of fibroblast growth factors 1 and 2 – implications for functions. Cytokine and Growth Factor Reviews. 2021. Feb:57:93-111. doi: 10.1016/j.cytogfr.2020.05.004.

Damiani I, Castiglioni S, Sochaj-Gregorczyk A, Bonacina F, Colombo I, Rusconi V, Otlewski J, Corsini A, Bellosta S.Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells. Biology (B asel). 2021 Aug 7;10(8):758. doi: 10.3390/biology10080758.

Poźniak M, Zarzycka W, Porębska N, Knapik A, Marczakiewicz-Perera P, Zakrzewska M, Otlewski J, Opaliński Ł. FGF1 Fusions with the Fc Fragment of IgG1 for the Assembly of GFPpolygons-Mediated Multivalent Complexes Recognizing FGFRs. Biomolecules. 2021 Jul 23;11(8):1088. doi: 10.3390/biom11081088.

Poźniak M, Porębska N, Krzyścik MA, Sokołowska-Wędzina A, Jastrzębski K, Sochacka M, Szymczyk J, Zakrzewska M, Otlewski J, Opaliński Ł. The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells., Mol Med. 2021 May 7;27(1):46. doi: 10.1186/s10020-021-00306-2.

Porębska N, Poźniak M, Matynia A, Żukowska D, Zakrzewska M, Otlewski J, Opaliński Ł.,Galectins as modulators of receptor tyrosine kinases signaling in health and disease.,Cytokine Growth Factor Rev. 2021 Mar 27:S1359-6101(21)00029-0. doi: 10.1016/j.cytogfr.2021.03.004.

Porebska N, Pozniak M, Krzyscik MA, Knapik A, Czyrek A, Kucinska M, Jastrzebski K, Zakrzewska M, Otlewski J, Opalinski L., Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1., Int J Biol Macromol. 2021 Jun 1;180:470-483. doi: 10.1016/j.ijbiomac.2021.03.094. Epub 2021 Mar 18.

Krzyscik,M.A., Sokolowska-Wedzina,A., Jendryczko,K., Pozniak,M., Nawrocka,D., Porebska,N.,Zakrzewska, M., Otlewski,J., Szlachcic, A. & Opalinski, L. Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation, (2021) JoVE Journal doi:10.3791/61918.

2020

Jendryczko,K.,Chudzian,J.,Skinder,N., Opaliński,Ł. Rzeszótko,J., Wiedlocha,A., Otlewski, J. & Szlachcic, A.(2020) FGF2-derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1. Cancers 12, 2992; doi:10.3390/cancers12102992

Sochacka, M., Opalinski, L., Szymczyk, J., Zimoch, M.B., Czyrek, A., ; Krowarsch, D., Otlewski, J., Zakrzewska, M.(2020) FHF1 is a Bona Fide Fibroblast Growth Factor that Activates Cellular Signaling in FGFR-dependent Manner. Cell Commun. Signaling 18, 69 doi: 10.1186/s12964-020-00573-2.

Sluzalska, K.D., Slawski, J., Sochacka, M., Lampart, A., Otlewski, J. & Zakrzewska, M. (2020). Intracellular partners of fibroblast growth factors 1 and 2 – implications for functions. Cytokine and Growth Factor Reviews. 18:S1359-6101(20)30043-5. doi: 10.1016/j.cytogfr.2020.05.004.

Pozniak, M., Sokolowska-Wedzina, A., Jastrzebski, K., Szymczyk, J., Porebska, N., Krzyscik, M.A., Zakrzewska, M., Miaczynska, M., Otlewski, J. & Opalinski, L. (2020) FGFR1 Clustering with Engineered Tetravalent Antibody Improves the Efficiency and Modifies the Mechanism of Receptor Internalization. Mol. Oncol.14,1 1998-2021. doi: 10.1002/1878-0261.12740.

Nawrocka, D., Krzyscik, M.A.,Opaliński,Ł., Zakrzewska, M. & Otlewski, J. (2020) Stable Fibroblast Growth Factor 2 Dimers with High Pro-survival and Mitogenic Potential. Int. J. Mol. Sci. 2, 4108.

Krzyscik, M., Zakrzewska, M. & Otlewski, J. (2020) Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1). Molecular Pharmaceutics 17, 2734-2748.

Duda, P., Wójtowicz, T., Janczara, J., Krowarsch, D., Czyrek, A., Gizak, A. & Rakus, D. (2020) Fructose 1,6-Bisphosphatase 2 Plays a Crucial Role in the Induction and Maintenance of Long-Term Potentiation. Cells. 9:1375. doi: 10.3390/cells9061375.

Doan KN, Grevel A, Martensson CU, Ellenrieder L, Thornton N, Wenz LS, Opaliński Ł, Guiard B, Pfanner N, Becker T (2020) The Mitochondrial Import Complex MIM Functions as Main Translocase for alpha-Helical Outer Membrane Protein, Cell Reports, 31(4):107567. doi: 10.1016/j.celrep.2020.107567.

2019

Szlachcic, A., Sochacka, M., Czyrek, A., Opalinski, L., Krowarsch, D., Otlewski, J. & Zakrzewska, M. (2019) Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity. Cells 15, 8, pii: E899. doi: 10.3390/cells8080899.

Krzyscik, M.; Opalinski, L. & Otlewski, J. (2019) Novel Method for Preparation of Site-Specific, Stoichiometric-Controlled Dual Warhead Conjugate of FGF2 via Dimerization Employing Sortase A-Mediated Ligation. Molecular Pharmaceutics 16, 3588-3599. doi: 10.1021/acs.molpharmaceut.9b00434.

Latko, M., Czyrek, A., Porębska, N., Kucińska, M., Otlewski, J., Zakrzewska, M. & Opaliński, L. (2019) Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins. Cells 2019, 8, 455; doi:10.3390/cells8050455.

Kucinska, M., Porebska, N., Lampart, A., Latko, M., Knapik, A., Zakrzewska, M., Otlewski, J., Opalinski, L. (2019) Differential Regulation of Fibroblast Growth Factor Receptor 1 Trafficking and Function by Extracellular Galectins – Cell Communication and Signaling 17, 65. doi: 10.1186/s12964-019-0371-1.

Lipok, M., Szlachcic, A., Kindela, K., Czayrek, A. & Otlewski, J. (2019) Phage Display Selection of Peptide Antagonist of FGF1-FGFR1 Signaling Axis. FEBS Open Bio doi: 10.1002/2211-5463.12618.

Zakrzewska, M., Opalinski, L.,Haugsten, E.M., Otlewski, J., Wiedlocha, A. & (2019) Crosstalk between p38 and ERK 1/2 in Downregulation of FGF1-induced Signaling. – Int. J. Mol. Sci. doi: 10.3390/ijms20081826.

Porebska, N., Latko, M., Kucinska, M., Zakrzewska,M., Otlewski, J. & Opaliński, L. (2019) Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment. J. Clin. Medicine 8(1), 7; https://doi.org/10.3390/jcm8010007.

2018

Chudzian, J., Szlachcic, A., Zakrzewska, M., Czub, M., Pustula, M., Holak, T.A. Otlewski, J.(2018) Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity. Int. J. Mol. Sci. 19, 2470; doi: 10.3390/ijms19092470/.

Kostas, M., Lampart, A., Bober, J., Wiedlocha, A., Tomala, J., Krowarsch, D., Otlewski, J. & Zakrzewska, M. (2018) Translocation of Exogenous FGF1 and FGF2 Protects the Cell against Apoptosis Independently of Receptor Activation. J. Mol. Biol. pii: S0022-2836(18)30912-4. doi: 10.1016/j.jmb.2018.08.004.

Swiderska, K.W., Szlachcic, A., Czyrek, A., Zakrzewska, M. & Otlewski, J. (2018) FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1. Int J Mol Sci. 19:2098, doi: 10.3390/ijms19072098

Opaliński, Ł., Szymczyk, J., Szczepara,M., Kucińska,M., Krowarsch, D., Zakrzewska,M. & Otlewski, J. (2018) High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1. Int. J. Mol. Sci. 10;19(5). pii: E1435. doi: 10.3390/ijms19051435.

Borek, A., Sokolowska-Wedzina, A., Chodaczek, G. & Otlewski, J. (2018) Generation of High-affinity, Internalizing Anti-FGFR2 Single-chain Variable Antibody Fragment Fused with Fc for Targeting Gastrointestinal Cancers. PLoS One doi: 10.1371/journal.pone.0192194.

Opaliński Ł, Song J, Priesnitz C, Wenz LS, Oeljeklaus S, Warscheid B, Pfanner N, Becker T, Pfanner N. (2018) Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis, Cell Reports, 25(8):2036-2043.e5. doi: 10.1016/j.celrep.2018.10.083.

2017

Sochaj-Gregorczyk, A.M., Ludzia, P., Kozdrowska, E., Jakimowicz, P., Sokolowska-Wedzina, A. & Otlewski, J. (2017) Design and In Vitro Evaluation of a Cytotoxic Conjugate Based on the Anti HER2-affibody Fused to the Fc Fragment of IgG1. Int. J. Mol. Sci. 18, 1688, doi:10.3390/ijms18081688.

Opalinski, L. Sokolowska-Wedzina, A., Szczepara, M., Zakrzewska, M. & Otlewski, J. (2017) Antibody-induced Dimerization of FGFR1 Promotes Receptor Endocytosis Independently of Its Kinase Activity. Scientific Reports 7, 7121. doi: 10.1038/s41598-017-07479-z.

Krzyscik, M. A., Zakrzewska, M., Sørensen, V., Sokolowska-Wedzina, A., Lobocki, M., Swiderska, K., Krowarsch, D., Wiedlocha, A. & Otlewski, J. (2017) Cytotoxic Conjugates of Fibroblast Growth Factor 2 with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors. ACS Omega 2 (7), 3792–3805.

Opalinski, L., Szczepara, M., Sokolowska-Wedzina, A., Zakrzewska, M. & Otlewski, J. (2017) The Autoinhibitory Function of D1 Domain of FGFR1 Goes Beyond the Inhibition of Ligand Binding. Int. J. Biochem. Cell Biol. 89, 193-198. doi: 10.1016/j.biocel.2017.06.015.

Lobocki, M., Zakrzewska, M., Szlachcic, A., Krzyscik, M.A., Sokolowska-Wedzina, A. & Otlewski, J. (2017) High-yield Site-specific Conjugation of Fibroblast Growth Factor 1 with Monomethylauristatin E via Cysteine Flanked by Basic Residues. Bioconjugate Chem. 28, 1850-1858. doi: 10.1021/acs.bioconjchem.7b00158.

Swiderska, K.W., Szlachcic, A., Czyrek, A., Zakrzewska, M. & Otlewski, J. (2017) Site-specific Conjugation of Fibroblast Growth Factor 2 (FGF2) Based on Incorporation of Alkyne-reactive Unnatural Amino Acid. Bioorg. Med. Chem. doi: 10.1016/j.bmc.2017.05.003.

Sokolowska-Wedzina, A., Chodaczek, G., Chudzian, J., Borek, A., Zakrzewska, M. & Otlewski, J. (2017) Generation of High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer Cells. Mol. Cancer Res. doi: 10.1158/1541-7786.MCR-16-0136.

Serwotka-Suszczak, A.M., Sochaj-Gregorczyk, A.M., Pieczykolan, J., Krowarsch, D., Jelen,F. & Otlewski, J. (2017) A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-positive Cancer Cells. Int. J. Mol. Sci. 18(2), 401; doi:10.3390/ijms18020401.

Jurek,P. M.,Zablocki,K.,Wasko,U.,Mazurek, M.P.,Otlewski,J. & Jelen, F. (2017) Anti-FGFR1 Aptamer-tagged Superparamagnetic Conjugates for Anti-cancer Hyperthermia. Int. J. Nanomedicine 12, 2941-2950.

Nillegoda NB, Stank A, Malinverni D, Alberts N, Szlachcic A, Barducci A, De Los Rios P, Wade RC, Bukau B. Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes. Elife. 2017 6:e24560.

2016

Sochaj-Gregorczyk, A. Serwotka, A. & Otlewski, J. (2016) Novel Affibody-auristatin E Conjugate with a Potent and Selective Activity against HER2-positive Cell Lines. J. Immunotherapy 39, 223-232.

Szlachcic, A., Zakrzewska, M. Łobocki, M., Jakimowicz, P. Otlewski, J. (2016) Design and Characteristics of Cytotoxic Fibroblast Growth Factor 1 (FGF1) Conjugate for the FGF Receptor-targeted Cancer Therapy. Drug Design, Development and Therapy 10, 2547-2560.

Bober, J., Olsnes, S., Kostas, M., Bogacz, M., Zakrzewska, M. & Otlewski, J. (2016) Identification of New FGF1 Binding Partners – Implications for its Intracellular Function. IUBMB Life. 68, 242-251.

Ellenrieder L, Opaliński Ł, Becker L, Kruger V, Mirus O, Ebell K, Flinner N, Stiller SB, Guiard B, Meisinger C, Wiedemann N, Schleiff E, Wagner R, Pfanner N, Becker T (2016) Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10, Nature Communications, 7:13021. doi: 10.1038/ncomms13021.

Kummer, E., Szlachcic, A., Franke, K. B., Ungelenk, S., Bukau, B., Mogk, A. Bacterial and Yeast AAA+ Disaggregases ClpB and Hsp104 Operate through Conserved Mechanism Involving Cooperation with Hsp70. J Mol Biol. 2016 428(21):4378-4391.

2015

Otlewski, J. & Wezner-Ptasinska, M. (2015) Selection of Specific Interactors from Phage Display Library Based on Sea Lamprey Variable Lymphocyte Receptor Sequences. Biochim. Biophys. Acta Protein and Proteomics 1854, 1833-1841.

Petters, E., Sokolowska-Wedzina, A. Otlewski, J. (2015) Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule. Int. J. Mol. Sci. 16, 19920-19935.

Sochaj, A.M., Swiderska, K.W. & Otlewski, J (2015) Current Methods for the Synthesis of Homogeneous Antibody-drug Conjugates. Biotechnology Advances 33, 775-784.

Pala, K., Jakimowicz,P., Cyranka, A.& Otlewski, J. (2015) The Synthesis of Multifunctional Nanoparticles Conjugated with Anti-Her2 Affibody and Monomethylauristatin E. Materials Research Express 2, 045403, doi.org/10.1088/2053-1591/2/4/045403

Buchtova, M., Vesela, I., Zakrzewska, M., Chaloupkova, R., Cela, P., Zajickova, R., Trantirek, L., Martin, J., Balek, L.,Kostas, M., Otlewski, J., Damborsky, J., Kozubik,A.,, Wiedlocha, A. & Krejci, P. (2015) Instability Restricts Signaling of Multiple Fibroblast Growth Factors. Cellular and Molecular Life Sciences 72, 2445-2459.

Nillegoda, N. B., Kirstein, J., Szlachcic, A., Berynskyy, M., Stank, A., Stengel, F., Arnsburg, K., Gao, X., Scior, A., Aebersold, R., Guilbride, D. L., Wade, R. C., Morimoto, R. I., Mayer, M. P., Bukau, B. Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation. Nature. 2015 524(7564):247-51.

Gao, X., Carroni, M., Nussbaum-Krammer, C., Mogk, A., Nillegoda, N. B., Szlachcic, A., Guilbride, D. L., Saibil, H. R., Mayer, M. P., Bukau, B. Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils. Mol Cell. 2015 59(5):781-93.

Wawiórka, L., Krokowski, D., Gordiyenko, Y., Krowarsch, D., Robinson, C.V., Adam, I., Grankowski, N. & Tchórzewski, M. (2015) In vivo formation of Plasmodium falciparum ribosomal stalk – a unique mode of assembly without stable heterodimeric intermediates. Biochim Biophys Acta. 1850, 150-158.

Williams C, Opaliński Ł, Landgraf C, Costello J, Schrader M, Krikken AM, Knoops K, Kram AM, Volkmer R, van der Klei IJ (2015) The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission, Proc Natl Acad Sci U S A, 112(20):6377-82. doi: 10.1073/pnas.1418736112.

Wenz LS, Opaliński Ł, Wiedemann N, Becker T (2015) Cooperation of protein machineries in mitochondrial protein sorting, Biochimica et Biophysica Acta-Molecular Cell Research, 1853: 1119-1129 doi: 10.1016/j.bbamcr.2015.01.012.

2014

Sokolowska-Wedzina, A., Borek, A., Chudzian, J., Jakimowicz, P., Zakrzewska, M. & Otlewski, J. (2014) Efficient Production and Purification of Extracellular Domain of Human FGFR-Fc Fusion Proteins from Chinese Hamster Ovary Cells. Protein Expression Purif. 99C, 50-57.

Pala K, Serwotka A, Jeleń F, Jakimowicz P. & Otlewski J. (2014) Tumor-specific Hyperthermia with Aptamer-tagged Superparamagnetic Nanoparticles. Int. J. Nanomedicine. 9, 67-76.

Kobielak, A., Zakrzewska, M., Kostaś,, M., Jakimowicz, P., Otlewski, J. & Krowarsch, D. (2014) Protease Resistant Variants of FGF1 with Prolonged Biological Activity. Protein Peptide Lett. 21, 434-443.

Opaliński Ł, Becker T, Pfanner N, Clearing tail-anchored proteins from mitochondria (2014) Proc Natl Acad Sci U S A, 111: 7888-7889, doi: 10.1073/pnas.1406864111.

Ieva R, Schrempp SG, Opaliński Ł, Wollweber F, Höß P, Heißwolf AK, Gebert M, Zhang Y, Guiard B, Rospert S, Becker T, Chacinska A, Pfanner N, van der Laan M (2014), Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane, Molecular Cell, 56: 641-652, doi: 10.1016/j.molcel.2014.10.010.

Wenz LS, Opaliński Ł, Schuler MH, Ellenrieder L, Ieva R, Böttinger L, Qiu J, van der Laan M, Wiedemann N, Guiard B, Pfanner N, Becker T, The presequence pathway is involved in protein sorting to the mitochondrial outer membrane, EMBO Reports, 15: 678-85, doi: 10.1002/embr.201338144.

Nadratowska-Wesolowska, B., Haugsten, E.M., Zakrzewska, M., Jakimowicz, P., Zhen, Y., Pajdzik, D., Wesche, J. & Wiedlocha, A. (2014) RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789. Oncogene. 33(40), 4823-36. doi: 10.1038/onc.2013.425. [PubMed]

Sletten, T., Kostas, M., Bober, J., Sorensen, V., Yadollahi, M., Olsnes, S., Tomala, J., Otlewski, J., Zakrzewska, M. & Wiedlocha, A. (2014) Nucleolin Regulates Phosphorylation and Nuclear Export of Fibroblast Growth Factor 1 (FGF1). PLoS One 9(3), e90687 doi: 10.1371/journal.pone.0090687. eCollection 2014. [PubMed]

Sosicka, P., Jakimowicz, P., Olczak, T., Olczak, M. (2014) Short N-terminal region of UDP-galactose transporter (SLC35A2) is crucial for galactosylation of N-glycans. Biochem Biophys Res Commun. 454(4), 486-492. doi: 10.1016/j.bbrc.2014.10.098. [PubMed]

2013

Petters, E., Krowarsch, D. & Otlewski, J. (2013) Design, Expression and Characterization of a Highly Stable Tetratricopeptide-based Protein Scaffold for Phage Display Application. Acta Biochim. Polon. 60, 585-590.

Sletten, T., Kostas, M., Bober, J., Sorensen, V., Olsnes, S., Otlewski, J., Zakrzewska, M., Wiedlocha, A. (2013) Nucleolin Regulates Phosphorylation and Nuclear Export of Fibroblast Growth Factor 1 (FGF1) – PLoS ONE, 9(3): e90687. doi:10.1371/journal.pone.0090687.

Radom, F., Jurek, P.M., Mazurek, M.P., Otlewski, J. & Jelen, F. (2013) Aptamers: Molecules of Great Potential, Biotechnology Advances, 31, 1260-1274.

Zakrzewska, M.; Haugsten, E.M.; Nadratowska-Wesolowska, B.; Oppelt, A.; Hausott, B.; Jin, Y.; Otlewski, J.; Wesche, J.; Wiedlocha, A. (2013) ERK-Mediated Phosphorylation of Fibroblast Growth Factor Receptor 1 on Ser 777 Inhibits Signaling. Science Signaling 6 (262), ra11. [DOI: 10.1126/scisignal.2003087].

Olczak, M., Maszczak-Seneczko, D., Sosicka, P., Jakimowicz, P., Olczak, T. (2013) UDP-Gal/UDP-GlcNAc chimeric transporter complements mutation defect in mammalian cells deficient in UDP-Gal transporter. Biochem Biophys Res Commun. 434(3), 473-478. doi: 10.1016/j.bbrc.2013.03.098. [PubMed]

Maszczak-Seneczko, D., Sosicka, P., Olczak, T., Jakimowicz, P., Majkowski, M., Olczak M. (2013) UDP-N-acetylglucosamine transporter (SLC35A3) regulates biosynthesis of highly branched N-glycans and keratan sulfate. J Biol Chem. 288(30), 21850-21860. doi: 10.1074/jbc.M113.460543. [PubMed]

Kochanczyk, T., Jakimowicz, P., Krezel, A. (2013) Femtomolar Zn(II) affinity of minimal zinc hook peptides – a promising small tag for protein engineering. Chem Commun (Camb). 49(13), 1312-1314. doi: 10.1039/c2cc38174e. [PubMed]

2012

Otlewski, J. (2012) “DNA, Genes and Molecular Medicine” Przegląd Uniwersytecki, pismo informacyjne Uniwersytetu Wrocławskiego, 10, 10-12.

Szlachcic, A., Pala, K., Zakrzewska, M., Jakimowicz, P., Wiedlocha, A. & Otlewski, J. (2012). FGF1-gold Nanoparticle Conjugates Targeting FGFR Efficiently Decrease Cell Viability upon NIR Irradiation. Int. J. Nanomedicine 7, 5915 – 5927.

Cyranka-Czaja, A. & Otlewski, J. (2012) A Novel, Stable, Helical Scaffold as an Alternative Binder – Construction of Phage Display Libraries. Acta Biochim. Polon. 59, 383-390.

Sikorska, M., Krezel, A. & Otlewski, J. (2012) Femtomolar Zn2+ Affinity to LIM Domain of Elfin Protein Uncovers Crucial Contribution of Protein-Protein Interactions to Protein Stability. J. Inorganic Biochem.115C, 28-35.

Cyranka-Czaja, A., Wulhfard, S., Neri, D. & Otlewski, J. (2012) Selection and Characterization of Human Antibody Fragments Specific for Psoriasin – a Cancer Associated Protein. Biochem. Biophys. Res. Commun. 419, 250-255.

Opaliński Ł, Bartoszewska M, Fekken S, Liu H, de Boer R, van der Klei IJ, Veenhuis M and Kiel JAKW (2012) Peroxisome biogenesis in Penicillium chrysogenum is not dependent of the Pex11 family members or Pex16, PLOS One, 7(4):e3549

Bartoszewska M, Williams C, Kikhney A, Opaliński Ł, van Roermund CW, de Boer R, Veenhuis M, van der Klei IJ (2012), Peroxisomal proteostasis involves a Lon family protein that functions as protease and chaperone, Journal of Biological Chemistry, 2012, 287.

2011

Zakrzewska, M., Szlachcic, A. & Otlewski J. (2011) Tailoring Small Proteins Towards Biomedical Applications. Curr. Pharm. Biotechnol. 12, 1792-1798.

Wezner-Ptasińska, M., Krowarsch, D., & Otlewski, J. (2011) Design and Characteristics of a Stable Protein Scaffold for Specific Binding Based on Variable Lymphocyte Receptor Sequences. Biochim. Biophys. Acta Protein and Proteomics 1814, 1140-1145.

Śmietana, K. , Mateja, A., Krężel, A. & Otlewski, J. (2011) PDZ Domain from Dishevelled – a Specificity Study. Acta Biochim. Polon. 58, 243-250.

Borowik, T., Przybylo, M., Pala, K., Otlewski, J. & Langner, M. (2011) Quantitative Measurement of Au and Fe in Ferromagnetic Nanoparticles with Laser Induced Breakdown Spectroscopy Using a Polymer-based Gel Matrix. Spectrochimica Acta Part B: Atomic Spectroscopy 66, 726-732.

Szlachcic, A., Zakrzewska, M. & Otlewski, J. (2011) Longer Action Means Better Drug: Tuning up Protein Therapeutics. Biotechnology Advances 29, 436-441.

Opaliński Ł, Veenhuis M, van der Klei IJ (2011) Peroxisomes: membrane events accompanying peroxisome proliferation, International Journal of Biochemistry and Cell Biology, 43: 847-51.

Bartoszewska M, Opaliński Ł, Veenhuis M, van der Klei IJ (2011) The significance of peroxisomes in secondary metabolite biosynthesis in filamentous fungi, Biotechnology Letters, 33: 1921-31

Opaliński Ł, Kiel JA, Williams C, Veenhuis M, van der Klei IJ (2011) Membrane curvature during peroxisome fission requires Pex11, EMBO Journal, 30: 5-16.

Maszczak-Seneczko, D., Olczak, T., Jakimowicz, P., Olczak, M. (2011) Overexpression of UDP-GlcNAc transporter partially corrects galactosylation defect caused by UDP-Gal transporter mutation. FEBS Lett. 585(19), 3090-3094. doi: 10.1016/j.febslet.2011.08.038. [PubMed]